Phosphine Induced Dimerization of Propargyl Alcohols Leading to Allyl Propargyl Ethers

Rhenium-catalyzed coupling of propargyl alcohols and allyl silanes.

A mild method for the regioselective coupling of propargyl alcohols and allylsilanes is described. The method employs an air- and moisture-tolerant rhenium-oxo complex ((dppm)ReOCl3) as a catalyst for the formation of sp3-carbon-sp3-carbon bonds without the need for prior activation of the propargyl alcohol as a halide or pseudohalide. The stability of the high oxidation state rhenium complex a...

Palladium-catalyzed carbonylation of 2-(propargyl)allyl phosphates leading to highly unsaturated gamma-lactones.

Copper-mediated trifluoromethylation of propargyl acetates leading to trifluoromethyl-allenes.

A copper-mediated trifluoromethylation of propargyl acetates with S-(trifluoromethyl)diphenylsulfonium triflate leading to trifluoromethylated allenes in moderate to excellent yields is described.

Iron-catalyzed ene-type propargylation of diarylethylenes with propargyl alcohols.

The diarylalkenyl propargylic complex framework has been found in many natural products and medicinal regents. Herein, we have disclosed an unprecedented FeCl(3) catalyzed ene-type reaction of propargylic alcohols with 1,1-diaryl alkenes which enabled us to furnish a diarylalkenyl propargylic complex framework in moderate to high chemical yields (up to 98%).

Indium-catalyzed intramolecular hydroarylation of aryl propargyl ethers.

Indium(III) halides catalyze efficiently the intramolecular hydroarylation (IMHA) of aryl propargyl ethers. The reaction proceeds regioselectively with terminal and internal alkynes bearing electron-rich and electron-deficient substituents in the benzenes and alkynes affording only the 6-endo dig cyclization product. Additionally, a sequential indium-catalyzed IMHA and palladium-catalyzed Sonog...